The aim of the present investigation was to prepare bioresponsive delivery systems of Moxifloxacin Hydrochloride for ophthalmic use which are in liquid state under storage conditions and turn into a gel upon instillation into the eye. Various polymers which undergo phase transition upon change in temperature and/or pH were used to prepare the formulations. The prepared formulations were characterized for drug content, clarity, transparency, pH, in-vitro drug release. Ocular irritancy potential of the optimized formulation was tested using HET CAM test. In-vivo studies were performed using rabbits to evaluate the ocular irritation potential and precorneal residence time of the prepared formulation. The prepared formulations exhibited all the desired characteristics such as optimum drug content, pH, transparency and lack of irritation. The formulations were also able to withstand sterilization by autoclaving and were found to be stable on storage. The ocular retention time of the prepared formulations was significantly higher than that of the marketed preparation. Phase transition systems of Moxifloxacin Hydrochloride seem to be promising in enhancing the precorneal residence time and thus reducing the frequency of administration.
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